Multivariable analysis for EFS and OS in the training cohort
| Covariate . | HR . | 95% CI . | P . |
|---|---|---|---|
| EFS | |||
| sIPI | .001 | ||
| Low | 1 | ||
| Low-intermediate | 2.52 | 1.26-5.04 | |
| High-intermediate or high | 3.62 | 1.79-7.32 | |
| Pretransplant DS | <.001 | ||
| 1-3 | 1 | ||
| 4 | 3.01 | 1.71-5.31 | |
| 5 | 13.46 | 5.99-30.22 | |
| B symptoms | .021 | ||
| Absence | 1 | ||
| Presence | 1.97 | 1.11-3.52 | |
| Bulky disease | .730 | ||
| No | 1 | ||
| Yes | 0.90 | 0.50-1.64 | |
| Response to previous therapy | .570 | ||
| ≥1 y | 1 | ||
| <1 y or refractory disease | 1.18 | 0.66-2.10 | |
| OS | |||
| sIPI | <.001 | ||
| Low | 1 | ||
| Low-intermediate | 2.34 | 0.99-5.53 | |
| High-intermediate or high | 5.22 | 2.28-11.96 | |
| Pretransplant DS | <.001 | ||
| 1-3 | 1 | ||
| 4 | 3.35 | 1.76-6.38 | |
| 5 | 9.63 | 3.78-24.52 | |
| B symptoms | .019 | ||
| Absence | 1 | ||
| Presence | 2.12 | 1.13-3.97 | |
| Bulky disease | .700 | ||
| No | 1 | ||
| Yes | 0.88 | 0.46-1.68 | |
| Response to previous therapy | .640 | ||
| ≥1 y | 1 | ||
| <1 y or refractory disease | 1.16 | 0.62-2.19 |
| Covariate . | HR . | 95% CI . | P . |
|---|---|---|---|
| EFS | |||
| sIPI | .001 | ||
| Low | 1 | ||
| Low-intermediate | 2.52 | 1.26-5.04 | |
| High-intermediate or high | 3.62 | 1.79-7.32 | |
| Pretransplant DS | <.001 | ||
| 1-3 | 1 | ||
| 4 | 3.01 | 1.71-5.31 | |
| 5 | 13.46 | 5.99-30.22 | |
| B symptoms | .021 | ||
| Absence | 1 | ||
| Presence | 1.97 | 1.11-3.52 | |
| Bulky disease | .730 | ||
| No | 1 | ||
| Yes | 0.90 | 0.50-1.64 | |
| Response to previous therapy | .570 | ||
| ≥1 y | 1 | ||
| <1 y or refractory disease | 1.18 | 0.66-2.10 | |
| OS | |||
| sIPI | <.001 | ||
| Low | 1 | ||
| Low-intermediate | 2.34 | 0.99-5.53 | |
| High-intermediate or high | 5.22 | 2.28-11.96 | |
| Pretransplant DS | <.001 | ||
| 1-3 | 1 | ||
| 4 | 3.35 | 1.76-6.38 | |
| 5 | 9.63 | 3.78-24.52 | |
| B symptoms | .019 | ||
| Absence | 1 | ||
| Presence | 2.12 | 1.13-3.97 | |
| Bulky disease | .700 | ||
| No | 1 | ||
| Yes | 0.88 | 0.46-1.68 | |
| Response to previous therapy | .640 | ||
| ≥1 y | 1 | ||
| <1 y or refractory disease | 1.16 | 0.62-2.19 |