Treatment-emergent AEs during KRd*
| AE . | KRd + ASCT (n = 76) . | |
|---|---|---|
| All grades, n (%) . | Grade 3 to 4, n (%) . | |
| Hematologic | ||
| Thrombocytopenia | 47 (62) | 11 (14) |
| Anemia | 32 (42) | 9 (12) |
| Lymphopenia | 32 (42) | 24 (32) |
| Neutropenia | 30 (39) | 26 (34) |
| Nonhematologic | ||
| Infection | 56 (74) | 17 (22) |
| Fatigue | 51 (67) | 4 (5) |
| Diarrhea | 39 (51) | 7 (9) |
| Hyperglycemia | 33 (43) | 6 (8) |
| Dyspnoea | 30 (39) | 2 (3) |
| Peripheral neuropathy | 32 (42) | 0 |
| Rash | 33 (43) | 4 (5) |
| Hypophosphatemia | 22 (29) | 11 (14) |
| Hypertension | 15 (20) | 4 (5) |
| Thromboembolic events | 14 (18) | 5 (7) |
| Cardiac events† | 10 (13) | 2 (3) |
| AE . | KRd + ASCT (n = 76) . | |
|---|---|---|
| All grades, n (%) . | Grade 3 to 4, n (%) . | |
| Hematologic | ||
| Thrombocytopenia | 47 (62) | 11 (14) |
| Anemia | 32 (42) | 9 (12) |
| Lymphopenia | 32 (42) | 24 (32) |
| Neutropenia | 30 (39) | 26 (34) |
| Nonhematologic | ||
| Infection | 56 (74) | 17 (22) |
| Fatigue | 51 (67) | 4 (5) |
| Diarrhea | 39 (51) | 7 (9) |
| Hyperglycemia | 33 (43) | 6 (8) |
| Dyspnoea | 30 (39) | 2 (3) |
| Peripheral neuropathy | 32 (42) | 0 |
| Rash | 33 (43) | 4 (5) |
| Hypophosphatemia | 22 (29) | 11 (14) |
| Hypertension | 15 (20) | 4 (5) |
| Thromboembolic events | 14 (18) | 5 (7) |
| Cardiac events† | 10 (13) | 2 (3) |
AEs with rate of >10% for any grade; events during ASCT and single-agent lenalidomide maintenance were not captured per protocol.
Two patients had asymptomatic left ventricular ejection fraction of 45% to 50% pretransplant, and one had a transient decline of left ventricular ejection fraction to 47% associated with hypertension during KRd maintenance.