Cox regression univariate and multivariate analyses of risk factors for CNS relapse
| . | HR (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age >60 y | 1.130 (0.477-2.675) | .781 |
| LDH | 2.762 (1.279-5.962) | .010 |
| EBV DNA | 3.199 (1.282-7.982) | .013 |
| Extranodal involvement ≥2 | 7.123 (3.246-15.629) | .001 |
| Distant LN involvement | 4.413 (2.040-9.549) | .001 |
| Ann Arbor stage III/IV | 6.665 (2.977-14.924) | .001 |
| PINK | ||
| Intermediate vs low | 3.717 (1.268-10.897) | .071 |
| High vs low | 7.288 (2.553-20.807) | .001 |
| High vs intermediate | 1.932 (0.832-4.484) | .125 |
| Intermediate/high vs low | 5.056 (1.908-13.397) | .001 |
| Multivariate analysis | ||
| Extranodal involvement ≥2 | 4.628 (1.974-10.852) | .001 |
| PINK intermediate/high | 2.677 (0.936-7.652) | .066 |
| . | HR (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age >60 y | 1.130 (0.477-2.675) | .781 |
| LDH | 2.762 (1.279-5.962) | .010 |
| EBV DNA | 3.199 (1.282-7.982) | .013 |
| Extranodal involvement ≥2 | 7.123 (3.246-15.629) | .001 |
| Distant LN involvement | 4.413 (2.040-9.549) | .001 |
| Ann Arbor stage III/IV | 6.665 (2.977-14.924) | .001 |
| PINK | ||
| Intermediate vs low | 3.717 (1.268-10.897) | .071 |
| High vs low | 7.288 (2.553-20.807) | .001 |
| High vs intermediate | 1.932 (0.832-4.484) | .125 |
| Intermediate/high vs low | 5.056 (1.908-13.397) | .001 |
| Multivariate analysis | ||
| Extranodal involvement ≥2 | 4.628 (1.974-10.852) | .001 |
| PINK intermediate/high | 2.677 (0.936-7.652) | .066 |
BM, bone marrow; LN, lymph node.