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Volume 99, Issue 3

February 1 2002

In this Issue

INSIDE BLOOD
PLENARY PAPERS
PERSPECTIVE
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

ATF4: a novel regulator of cell growth

Paul A. Ney

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Neutrophils at the crossroads of cytokine and RA receptors

Trang Hoang

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Another piece of the puzzle

David G. Maloney

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PLENARY PAPERS

Comparison of 200 mg/m² melphalan and 8 Gy total body irradiation plus 140 mg/m² melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myélome 9502 randomized trial
Clinical Trials & Observations

Philippe Moreau,Thierry Facon,Michel Attal,Cyrille Hulin,Mauricette Michallet,Frédéric Maloisel,Jean-Jacques Sotto,François Guilhot,Gérald Marit,Chantal Doyen,Jérôme Jaubert,Jean-Gabriel Fuzibet,Sylvie François,Lotfi Benboubker,Matthieu Monconduit,Laurent Voillat,Margaret Macro,Christian Berthou,Véronique Dorvaux,Bernard Pignon,Bernard Rio,Thomas Matthes,Philippe Casassus,Denis Caillot,Norbert Najman,Bernard Grosbois,Régis Bataille,Jean-Luc Harousseau,for the Intergroupe Francophone du Myélome

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Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice

Howard C. Masuoka,Tim M. Townes

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The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation

Barton S. Johnson,LeMoyne Mueller,Jutong Si,Steven J. Collins

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Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene

Guillaume Cartron,Laurent Dacheux,Gilles Salles,Philippe Solal-Celigny,Pierre Bardos,Philippe Colombat,Hervé Watier

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PERSPECTIVE

Acute promyelocytic leukemia: evolving therapeutic strategies
Clinical Trials & Observations

Martin S. Tallman,Chadi Nabhan,James H. Feusner,Jacob M. Rowe

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REVIEW ARTICLES

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?

Richard K. Burt,Shimon Slavin,William H. Burns,Alberto M. Marmont

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CHEMOKINES

Pathways for internalization and recycling of the chemokine receptor CCR5

Anja Mueller,Eamonn Kelly,Philip G. Strange

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Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice

Johanne Cashman,Ian Clark-Lewis,Allen Eaves,Connie Eaves

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients
Clinical Trials & Observations

Regina Fink-Puches,Paulus Zenahlik,Barbara Bäck,Josef Smolle,Helmut Kerl,Lorenzo Cerroni

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Superior survival associated with transplantation of matched unrelated versus one-antigen–mismatched unrelated or highly human leukocyte antigen– disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishing a treatment algorithm for recipients of alternative donor grafts
Clinical Trials & Observations

William R. Drobyski,John Klein,Neal Flomenberg,Daniel Pietryga,David H. Vesole,David A. Margolis,Carolyn A. Keever-Taylor

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De novo CD5⁺ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Clinical Trials & Observations

Motoko Yamaguchi,Masao Seto,Masataka Okamoto,Ryo Ichinohasama,Naoya Nakamura,Tadashi Yoshino,Junji Suzumiya,Takuhei Murase,Ikuo Miura,Takashi Akasaka,Jun-ichi Tamaru,Ritsuro Suzuki,Yoshitoyo Kagami,Masami Hirano,Yasuo Morishima,Ryuzo Ueda,Hiroshi Shiku,Shigeo Nakamura

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Therapy-related myelodysplastic syndrome–acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem
Clinical Trials & Observations

Roberto Latagliata,Maria Concetta Petti,Susanna Fenu,Marco Mancini,Maria Antonietta Aloe Spiriti,Massimo Breccia,Gregorio A. Brunetti,Giuseppe Avvisati,Francesco Lo Coco,Franco Mandelli

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Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group
Clinical Trials & Observations

Beverly J. Lange,Bruce C. Bostrom,Joel M. Cherlow,Martha G. Sensel,Mei K. L. La,Wayne Rackoff,Nyla A. Heerema,Robert S. Wimmer,Michael E. Trigg,Harland N. Sather

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Efficacy and safety of thalidomide in patients with acute myeloid leukemia
Clinical Trials & Observations

Martin B. Steins,Teresa Padró,Ralf Bieker,Sandra Ruiz,Martin Kropff,Joachim Kienast,Torsten Kessler,Thomas Buechner,Wolfgang E. Berdel,Rolf M. Mesters

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Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients
Clinical Trials & Observations

Francesco Onida,Hagop M. Kantarjian,Terry L. Smith,Greg Ball,Michael J. Keating,Elihu H. Estey,Armand B. Glassman,Maher Albitar,Monica I. Kwari,Miloslav Beran

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Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait
Clinical Trials & Observations

Elizabeth M. Kang,Ellen M. Areman,Virginia David-Ocampo,Courtney Fitzhugh,Mary E. Link,Elizabeth J. Read,Susan F. Leitman,Griffin P. Rodgers,John F. Tisdale

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Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma
Clinical Trials & Observations

Alessandro Rambaldi,Manuela Lazzari,Cristina Manzoni,Emanuela Carlotti,Luca Arcaini,Michele Baccarani,Tiziano Barbui,Carlo Bernasconi,Giuseppe Dastoli,Giovanna Fuga,Enrica Gamba,Livio Gargantini,Valter Gattei,Francesco Lauria,Mario Lazzarino,Franco Mandelli,Enrica Morra,Alessandro Pulsoni,Michela Ribersani,Pier Luigi Rossi-Ferrini,Maurizio Rupolo,Sante Tura,Vittorina Zagonel,Francesco Zaja,PierLuigi Zinzani,Gigliola Reato,Robin Foa

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Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study
Clinical Trials & Observations

Luciana Annino,Maria Luce Vegna,Andrea Camera,Giorgina Specchia,Giuseppe Visani,Giuseppe Fioritoni,Felicetto Ferrara,Antonio Peta,Stefania Ciolli,Wilma Deplano,Francesco Fabbiano,Simona Sica,Francesco Di Raimondo,Nicola Cascavilla,Antonio Tabilio,Pietro Leoni,Rosangela Invernizzi,Michele Baccarani,Bruno Rotoli,Sergio Amadori,Franco Mandelli,for the GIMEMA Group

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Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival
Clinical Trials & Observations

Laurie A. Myers,Dhavalkumar D. Patel,Jennifer M. Puck,Rebecca H. Buckley

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HEMATOPOIESIS

Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells

Shiva Akbarzadeh,Alister C. Ward,Dora O. M. McPhee,Warren S. Alexander,Graham J. Lieschke,Judith E. Layton

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Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34⁺ cells are correlated with different levels of platelet release

Gianfranco Mattia,Francesca Vulcano,Luisa Milazzo,Alessandra Barca,Giampiero Macioce,Adele Giampaolo,H. Jane Hassan

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Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms

Chris P. Miller,Destin W. Heilman,Don M. Wojchowski

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Lineage-specific defect in gene expression in human platelet phospholipase C-β2 deficiency

Guang Fen Mao,Vijender R. Vaidyula,Satya P. Kunapuli,A. Koneti Rao

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Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells

Rainer Wiewrodt,Anu P. Thomas,Luca Cipelletti,Melpo Christofidou-Solomidou,David A. Weitz,Sheldon I. Feinstein,David Schaffer,Steven M. Albelda,Michael Koval,Vladimir R. Muzykantov

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Mechanism of factor VIIa–dependent coagulation in hemophilia blood: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA.

Saulius Butenas,Kathleen E. Brummel,Richard F. Branda,Sara G. Paradis,Kenneth G. Mann

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Missense mutations in the β₃ subunit have a different impact on the expression and function between α_IIbβ₃ and α_vβ₃

Seiji Tadokoro,Yoshiaki Tomiyama,Shigenori Honda,Hirokazu Kashiwagi,Satoru Kosugi,Masamichi Shiraga,Teruo Kiyoi,Yoshiyuki Kurata,Yuji Matsuzawa

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Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition

Hong Wang,XiaoHua Jiang,Fan Yang,Gary B. Chapman,William Durante,Nicholas E. S. Sibinga,Andrew I. Schafer

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IMMUNOBIOLOGY

Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1

Gunther G. Pendl,Caroline Robert,Meike Steinert,Renate Thanos,Ruth Eytner,Eric Borges,Martin K. Wild,John B. Lowe,Robert C. Fuhlbrigge,Thomas S. Kupper,Dietmar Vestweber,Stephan Grabbe

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Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation

Duncan Howie,Marı́a Simarro,Joan Sayos,Maria Guirado,Jaime Sancho,Cox Terhorst

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Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins

Axel Lorentz,Detlef Schuppan,Andreas Gebert,Michael P. Manns,Stephan C. Bischoff

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Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Mette Nielsen,Mogens H. Nissen,Jens Gerwien,Mai-Britt Zocca,Helene M. Rasmussen,Koichi Nakajima,Carsten Röpke,Carsten Geisler,Keld Kaltoft,Niels Ødum

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Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function

Jaime Millán,Marı́a C. Montoya,David Sancho,Francisco Sánchez-Madrid,Miguel A. Alonso

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General T-cell receptor antagonists to immunomodulate HLA-A2–restricted minor histocompatibility antigen HA-1–specific T-cell responses

Joke M. M. den Haan,Tuna Mutis,Els Blokland,Ad P. IJzerman,Els Goulmy

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Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties

Christel Buelens,Emmanuel J. Bartholomé,Zoulikha Amraoui,Michael Boutriaux,Isabelle Salmon,Kris Thielemans,Fabienne Willems,Michel Goldman

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CD8α⁺ dendritic cells originate from the CD8α⁻ dendritic cell subset by a maturation process involving CD8α, DEC-205, and CD24 up-regulation

Gloria Martı́nez del Hoyo,Pilar Martı́n,Cristina Fernández Arias,Alvaro Rodrı́guez Marı́n,Carlos Ardavı́n

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Adenosine deaminase deficiency with mosaicism for a “second-site suppressor” of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy

Francisco X. Arredondo-Vega,Ines Santisteban,Eva Richard,Pawan Bali,Majed Koleilat,Michael Loubser,Abdulaziz Al-Ghonaium,Mariam Al-Helali,Michael S. Hershfield

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NEOPLASIA

Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk

Qi Zhu,Ji-Wang Zhang,Hai-Qing Zhu,Yu-Lei Shen,Maria Flexor,Pei-Ming Jia,Yun Yu,Xun Cai,Samuel Waxman,Michel Lanotte,Sai-Juan Chen,Zhu Chen,Jian-Hua Tong

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CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease

Terry J. Hamblin,Jenny A. Orchard,Rachel E. Ibbotson,Zadie Davis,Peter W. Thomas,Freda K. Stevenson,David G. Oscier

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Distinctive features of “nurselike” cells that differentiate in the context of chronic lymphocytic leukemia

Nobuhiro Tsukada,Jan A. Burger,Nathan J. Zvaifler,Thomas J. Kipps

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The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction

John C. Byrd,Shinichi Kitada,Ian W. Flinn,Jennifer L. Aron,Michael Pearson,David Lucas,John C. Reed

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PHAGOCYTES

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

Oliver Werz,Eva Bürkert,Bengt Samuelsson,Olof Rådmark,Dieter Steinhilber

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Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo

Frank M. Szaba,Stephen T. Smiley

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RED CELLS

Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells

Fiona K. Glenister,Ross L. Coppel,Alan F. Cowman,Narla Mohandas,Brian M. Cooke

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Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients

Bruno Venerando,Amelia Fiorilli,Gianluigi Croci,Cristina Tringali,Giancarlo Goi,Laura Mazzanti,Giovanna Curatola,Giovanni Segalini,Luca Massaccesi,Adriana Lombardo,Guido Tettamanti

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TRANSPLANTATION

Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen

Ronjon Chakraverty,Karl Peggs,Rajesh Chopra,Donald W. Milligan,Panagiotis D. Kottaridis,Stephanie Verfuerth,Johanne Geary,Dharsha Thuraisundaram,Kate Branson,Suparno Chakrabarti,Premini Mahendra,Charles Craddock,Anne Parker,Ann Hunter,Geoff Hale,Herman Waldmann,Catherine D. Williams,Kwee Yong,David C. Linch,Anthony H. Goldstone,Stephen Mackinnon

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BRIEF REPORTS

Partial deletion in the JK locus causing a Jk_null phenotype
Brief Report

Nicole Lucien,Jacques Chiaroni,Jean-Pierre Cartron,Pascal Bailly

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Regulation of fetal versus embryonic gamma globin genes: appropriate developmental stage expression patterns in the presence of HS2 of the locus control region
Brief Report

Timothy Yu,David M. Thomas,Wei Zhu,Morris Goodman,Deborah L. Gumucio

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Development of drug-resistant herpes simplex virus infection after haploidentical hematopoietic progenitor cell transplantation
Clinical Trials & Observations Brief Report

Amelia A. Langston,Istvan Redei,Angela M. Caliendo,Jyoti Somani,Don Hutcherson,Sagar Lonial,Silvana Bucur,Judy Cherry,Andrew Allen,Edmund K. Waller

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Sustained suppression of hepatitis C virus by interferon and ribavirin in hemophilic patients not responding to interferon monotherapy
Clinical Trials & Observations Brief Report

Elena Santagostino,Maria Grazia Rumi,Monica Rivi,Massimo Colombo,Pier Mannuccio Mannucci,for the Hepatitis Study Group of the Association of Italian Hemophilia Centers

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Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia
Brief Report

Hassan Ghazal

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CORRESPONDENCE

Bone marrow–derived cells contribute to endothelial repair after thrombotic microangiopathy

Maarten B. Rookmaaker,Herman Tolboom,Roel Goldschmeding,Jaap-Jan Zwaginga,Ton J. Rabelink,Marianne C. Verhaar

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Treatment of painful sickle cell leg ulcers with topical opioids

Samir K. Ballas

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Sustained response of refractory chronic lymphocytic leukemia in progression complicated by acute hemolitic anemia to anti-CD20 monoclonal antibody

Emilio Iannitto,Emanuele Ammatuna,Carla Marino,Sonia Cirrincione,Gioacchino Greco,Gugcielmo Mariani

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Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis

Damian James Hussey,Alexander Dobrovic

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Issue Archive

Table of Contents

INSIDE BLOOD

ATF4: a novel regulator of cell growth Free

Neutrophils at the crossroads of cytokine and RA receptors Free

Another piece of the puzzle Free

PLENARY PAPERS

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice Free

The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation Free

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene Free

PERSPECTIVE

Acute promyelocytic leukemia: evolving therapeutic strategies Free Clinical Trials & Observations

REVIEW ARTICLES

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Free

CHEMOKINES

Pathways for internalization and recycling of the chemokine receptor CCR5 Free

Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice Free

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients Free Clinical Trials & Observations

De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients Free Clinical Trials & Observations

Therapy-related myelodysplastic syndrome–acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem Free Clinical Trials & Observations

Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group Free Clinical Trials & Observations

Efficacy and safety of thalidomide in patients with acute myeloid leukemia Free Clinical Trials & Observations

Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients Free Clinical Trials & Observations

Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait Free Clinical Trials & Observations

Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma Free Clinical Trials & Observations

Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study Free Clinical Trials & Observations

Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival Free Clinical Trials & Observations

HEMATOPOIESIS

Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells Free

Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release Free

Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Lineage-specific defect in gene expression in human platelet phospholipase C-β2 deficiency Free

Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells Free

Mechanism of factor VIIa–dependent coagulation in hemophilia blood: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA. Free

Missense mutations in the β3 subunit have a different impact on the expression and function between αIIbβ3 and αvβ3 Free

Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition Free

IMMUNOBIOLOGY

Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1 Free

Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation Free

Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins Free

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3 Free

Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function Free

General T-cell receptor antagonists to immunomodulate HLA-A2–restricted minor histocompatibility antigen HA-1–specific T-cell responses Free

Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties Free

CD8α+ dendritic cells originate from the CD8α− dendritic cell subset by a maturation process involving CD8α, DEC-205, and CD24 up-regulation Free

Adenosine deaminase deficiency with mosaicism for a “second-site suppressor” of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy Free

NEOPLASIA

Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk Free

CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease Free

Distinctive features of “nurselike” cells that differentiate in the context of chronic lymphocytic leukemia Free

The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction Free

PHAGOCYTES

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes Free

Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo Free

RED CELLS

Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells Free

Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients Free

TRANSPLANTATION

Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen Free

BRIEF REPORTS

Partial deletion in the JK locus causing a Jknull phenotype Free Brief Report

Regulation of fetal versus embryonic gamma globin genes: appropriate developmental stage expression patterns in the presence of HS2 of the locus control region Free Brief Report

Development of drug-resistant herpes simplex virus infection after haploidentical hematopoietic progenitor cell transplantation Free Clinical Trials & Observations Brief Report

Sustained suppression of hepatitis C virus by interferon and ribavirin in hemophilic patients not responding to interferon monotherapy Free Clinical Trials & Observations Brief Report

Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia Free Brief Report

CORRESPONDENCE

Bone marrow–derived cells contribute to endothelial repair after thrombotic microangiopathy Free

Treatment of painful sickle cell leg ulcers with topical opioids Free

Sustained response of refractory chronic lymphocytic leukemia in progression complicated by acute hemolitic anemia to anti-CD20 monoclonal antibody Free

Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis Free

Email alerts

ASH Publications

American Society of Hematology

ATF4: a novel regulator of cell growth

Neutrophils at the crossroads of cytokine and RA receptors

Another piece of the puzzle

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice

The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene

Acute promyelocytic leukemia: evolving therapeutic strategies
Clinical Trials & Observations

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?

Pathways for internalization and recycling of the chemokine receptor CCR5

Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice

Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients
Clinical Trials & Observations

De novo CD5⁺ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Clinical Trials & Observations

Therapy-related myelodysplastic syndrome–acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem
Clinical Trials & Observations

Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group
Clinical Trials & Observations

Efficacy and safety of thalidomide in patients with acute myeloid leukemia
Clinical Trials & Observations

Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients
Clinical Trials & Observations

Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait
Clinical Trials & Observations

Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma
Clinical Trials & Observations

Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study
Clinical Trials & Observations

Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival
Clinical Trials & Observations

Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells

Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34⁺ cells are correlated with different levels of platelet release

Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms

Lineage-specific defect in gene expression in human platelet phospholipase C-β2 deficiency

Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells

Mechanism of factor VIIa–dependent coagulation in hemophilia blood: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA.

Missense mutations in the β₃ subunit have a different impact on the expression and function between α_IIbβ₃ and α_vβ₃

Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition

Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1

Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation

Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function

General T-cell receptor antagonists to immunomodulate HLA-A2–restricted minor histocompatibility antigen HA-1–specific T-cell responses

Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties

CD8α⁺ dendritic cells originate from the CD8α⁻ dendritic cell subset by a maturation process involving CD8α, DEC-205, and CD24 up-regulation

Adenosine deaminase deficiency with mosaicism for a “second-site suppressor” of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy

Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk

CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease

Distinctive features of “nurselike” cells that differentiate in the context of chronic lymphocytic leukemia

The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo

Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells

Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients

Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen

Partial deletion in the JK locus causing a Jk_null phenotype
Brief Report

Regulation of fetal versus embryonic gamma globin genes: appropriate developmental stage expression patterns in the presence of HS2 of the locus control region
Brief Report

Development of drug-resistant herpes simplex virus infection after haploidentical hematopoietic progenitor cell transplantation
Clinical Trials & Observations Brief Report

Sustained suppression of hepatitis C virus by interferon and ribavirin in hemophilic patients not responding to interferon monotherapy
Clinical Trials & Observations Brief Report

Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia
Brief Report

Bone marrow–derived cells contribute to endothelial repair after thrombotic microangiopathy

Treatment of painful sickle cell leg ulcers with topical opioids

Sustained response of refractory chronic lymphocytic leukemia in progression complicated by acute hemolitic anemia to anti-CD20 monoclonal antibody

Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis