Sharyne M. Donfield,for the Hemophilia Growth and Development Study Group,Henry S. Lynn,for the Hemophilia Growth and Development Study Group,Alice E. Lail,for the Hemophilia Growth and Development Study Group,W. Keith Hoots,for the Hemophilia Growth and Development Study Group,Erik Berntorp,for the Hemophilia Growth and Development Study Group,Edward D. Gomperts,for the Hemophilia Growth and Development Study Group

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

IMMUNOBIOLOGY

Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment

Katja Janssen,Stephan Pohlmann,Reiner U. Jänicke,Klaus Schulze-Osthoff,Ute Fischer

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis

Philip O. Scumpia,Matthew J. Delano,Kindra M. Kelly-Scumpia,Jason S. Weinstein,James L. Wynn,Robert D. Winfield,Changqing Xia,Chun Shiang Chung,Alfred Ayala,Mark A. Atkinson,Westley H. Reeves,Michael J. Clare-Salzler,Lyle L. Moldawer

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin–mediated human T-cell adhesion

Haifa Ghandour,Xavier Cullere,Angeles Alvarez,Francis W. Luscinskas,Tanya N. Mayadas

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells
Brief Report

Dominique Chabannes,Marcelo Hill,Emmanuel Merieau,Julien Rossignol,Régis Brion,Jean Paul Soulillou,Ignacio Anegon,Maria Cristina Cuturi

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

NEOPLASIA

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha

Steffen Koschmieder,Francesco D'Alò,Hanna Radomska,Christine Schöneich,Ji Suk Chang,Marina Konopleva,Susumu Kobayashi,Elena Levantini,Nanjoo Suh,Annalisa Di Ruscio,Maria Teresa Voso,Julie C. Watt,Ramasamy Santhanam,Bülent Sargin,Hagop Kantarjian,Michael Andreeff,Michael B. Sporn,Danilo Perrotti,Wolfgang E. Berdel,Carsten Müller-Tidow,Hubert Serve,Daniel G. Tenen

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Bas J. Wouters,Meritxell Alberich Jordà,Karen Keeshan,Irene Louwers,Claudia A. J. Erpelinck-Verschueren,Dennis Tielemans,Anton W. Langerak,Yiping He,Yumi Yashiro-Ohtani,Pu Zhang,Christopher J. Hetherington,Roel G. W. Verhaak,Peter J. M. Valk,Bob Löwenberg,Daniel G. Tenen,Warren S. Pear,Ruud Delwel

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

Christoph Mancao,Wolfgang Hammerschmidt

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Histone deacetylase–mediated transcriptional activation reduces proviral loads in HTLV-1–associated myelopathy/tropical spastic paraparesis patients

Agnès Lezin,Nicolas Gillet,Stéphane Olindo,Aïssatou Signaté,Nathalie Grandvaux,Olivier Verlaeten,Gildas Belrose,Marcelo de Carvalho Bittencourt,John Hiscott,Becca Asquith,Arsène Burny,Didier Smadja,Raymond Césaire,Luc Willems

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome

Andrew Chase,Francis H. Grand,Nicholas C. P. Cross

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis

Ronan Chaligné,Chloé James,Carole Tonetti,Rodolphe Besancenot,Jean Pierre Le Couédic,Fanny Fava,Fréderic Mazurier,Isabelle Godin,Karim Maloum,Frédéric Larbret,Yann Lécluse,William Vainchenker,Stéphane Giraudier

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

Sonia Vallet,Noopur Raje,Kenji Ishitsuka,Teru Hideshima,Klaus Podar,Shweta Chhetri,Samantha Pozzi,Iris Breitkreutz,Tanyel Kiziltepe,Hiroshi Yasui,Enrique M. Ocio,Norihiko Shiraishi,Janice Jin,Yutaka Okawa,Hiroshi Ikeda,Siddhartha Mukherjee,Nileshwari Vaghela,Diana Cirstea,Marco Ladetto,Mario Boccadoro,Kenneth C. Anderson

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis

Joachim R. Göthert,Rachael L. Brake,Monique Smeets,Ulrich Dührsen,C. Glenn Begley,David J. Izon

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

PHAGOCYTES

Histone H2B as a functionally important plasminogen receptor on macrophages

Riku Das,Tim Burke,Edward F. Plow

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

Gα_i2 is required for chemokine-induced neutrophil arrest

Alexander Zarbock,Tracy L. Deem,Tracy L. Burcin,Klaus Ley

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

RED CELLS

Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations
Brief Report

Ivana De Domenico,Michael B. Vaughn,Donghoon Yoon,James P. Kushner,Diane M. Ward,Jerry Kaplan

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

TRANSPLANTATION

Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study

Smita Bhatia,Liton Francisco,Andrea Carter,Can-Lan Sun,K. Scott Baker,James G. Gurney,Philip B. McGlave,Auayporn Nademanee,Margaret O'Donnell,Norma K. C. Ramsay,Leslie L. Robison,David Snyder,Anthony Stein,Stephen J. Forman,Daniel J. Weisdorf

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4⁺CD25⁺Foxp3⁺ regulatory T cells

Shigeharu Fujita,Yumiko Sato,Kaori Sato,Kawori Eizumi,Tomohiro Fukaya,Masato Kubo,Naohide Yamashita,Katsuaki Sato

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Absence of regulatory T-cell control of T_H1 and T_H17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease

Xiao Chen,Sanja Vodanovic-Jankovic,Bryon Johnson,Melissa Keller,Richard Komorowski,William R. Drobyski

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Supplemental data

CORRESPONDENCE

Lenalidomide-induced severe hepatotoxicity

Subuhee Hussain,Royston Browne,Julie Chen,Samir Parekh

View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

Cover Image
Front Matter
Table of Contents
Back Matter
Advertising
Editorial Board

All Issues

Advertisement intended for health care professionals

Email alerts

First Edition Alert

Latest Issue Alert

Close Modal

Latest
Most Read
Most Cited

The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy

RGI-2001 for the Prophylaxis of Acute Graft-Versus-Host Disease Following Allogeneic HCT

Type 1 von Willebrand disease: does it need a sibling?

Duployez N, Largeaud L, Duchmann M, et al. Prognostic impact of DDX41 germline mutations in intensively treated acute myeloid leukemia patients: an ALFA-FILO study. Blood. 2022;140(7):756-768.

Qualitative low VWF

Advertisement intended for health care professionals

Issue Archive

Table of Contents

INSIDE BLOOD

Lycat: new targets in hemangioblast differentiation? Free

Amyloidosis: graviores morbos, asperis remedii Free

AML: treatment-related toxicity or not? Free

Taxol therapy revisited Free

A wrinkle in the unfolding of hypoxic response: HIF and ATF4 Free

Hematopoietic cell transplantation: a lifelong commitment Free

Viral mimic for B-cell survival Free

Hyperhomocysteinemia: DNA hypomethylation and endothelial degeneration Free

Rap1: selective activator of β2 integrins? Free

Regulatory T cells and the pursuit of self-tolerance Free

REVIEW IN TRANSLATIONAL HEMATOLOGY

Immunomodulatory properties of mesenchymal stromal cells Free

The role of FDG-PET scans in patients with lymphoma Free

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway Free

CLINICAL TRIALS AND OBSERVATIONS

Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP) Free Clinical Trials & Observations

Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia Free Clinical Trials & Observations

Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome–positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance Free Clinical Trials & Observations

Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia Free Clinical Trials & Observations

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing Free Clinical Trials & Observations

Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial Free Brief Report

Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation Free Brief Report

GENE THERAPY

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma Free

HEMATOPOIESIS

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene Free

The Shc-binding site of the βc subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis Free

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways Free

Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation Free

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor Free

The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development Free

The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans Open Access Brief Report

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish Free

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery Free

Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin Agene Free

Delays in maturation among adolescents with hemophilia and a history of inhibitors Free

IMMUNOBIOLOGY

Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment Free

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis Free

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin–mediated human T-cell adhesion Free

A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells Free Brief Report

NEOPLASIA

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha Free

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1 Free

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival Free

Histone deacetylase–mediated transcriptional activation reduces proviral loads in HTLV-1–associated myelopathy/tropical spastic paraparesis patients Free

Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome Free

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis Free

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts Free

NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis Free

PHAGOCYTES

Histone H2B as a functionally important plasminogen receptor on macrophages Free

Gαi2 is required for chemokine-induced neutrophil arrest Free

RED CELLS

Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations Free Brief Report

TRANSPLANTATION

Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study Free

Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells Free

Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease Free

CORRESPONDENCE

Lenalidomide-induced severe hepatotoxicity Free

Email alerts

ASH Publications

American Society of Hematology

Lycat: new targets in hemangioblast differentiation?

Amyloidosis: graviores morbos, asperis remedii

AML: treatment-related toxicity or not?

Taxol therapy revisited

A wrinkle in the unfolding of hypoxic response: HIF and ATF4

Hematopoietic cell transplantation: a lifelong commitment

Viral mimic for B-cell survival

Hyperhomocysteinemia: DNA hypomethylation and endothelial degeneration

Rap1: selective activator of β2 integrins?

Regulatory T cells and the pursuit of self-tolerance

Immunomodulatory properties of mesenchymal stromal cells

The role of FDG-PET scans in patients with lymphoma

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway

Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP)
Clinical Trials & Observations

Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia
Clinical Trials & Observations

Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome–positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
Clinical Trials & Observations

Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia
Clinical Trials & Observations

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing
Clinical Trials & Observations

Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial
Brief Report

Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation
Brief Report

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

The Shc-binding site of the β_c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways

Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development

The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans
Brief Report

Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery

Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin Agene

Delays in maturation among adolescents with hemophilia and a history of inhibitors

Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin–mediated human T-cell adhesion

A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells
Brief Report

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

Histone deacetylase–mediated transcriptional activation reduces proviral loads in HTLV-1–associated myelopathy/tropical spastic paraparesis patients

Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis

Histone H2B as a functionally important plasminogen receptor on macrophages

Gα_i2 is required for chemokine-induced neutrophil arrest

Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations
Brief Report

Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study

Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4⁺CD25⁺Foxp3⁺ regulatory T cells

Absence of regulatory T-cell control of T_H1 and T_H17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease

Lenalidomide-induced severe hepatotoxicity